The clinical implications of obesity have pervaded several specialties since treatments include medical and surgical intervention. In this issue, Dr. Thompson has created an issue that addresses topics of concern to endoscopists: important concerns in the endoscopic unit, presurgical evaluation, postoperative care, sedation, and endoscopic management of common complications. Further, special articles are included on endoscopic revisions to failed gastric bypass as well as reimbursement and regulatory issues.