In some non voluntary crime is crucial verify the amygdala and limbic system physio-pathology of human responsible of the facts under aJurisdictional contest.But is relevant to verify this condition in really objective and instrumental way.Many other human physio-pathological condition are deeply investigated using biochemical or imaging technique: today many organ and system are currently evaluated with high number of biomedical, instrumental or imaging test also In basal or stressing condition.The objective setting of amygdala and limbic system must be added in jurisdictional procedure not as a prove but an additional information to be correctly evaluated.In this work after a literature evaluation some global conclusion are produced.