This is the only book of its kind to serve the rapidly growing PBPK user community, developing principles from basics in clear, concise language. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. * Sets itself apart with its unique comprehensive coverage of PBPK modelling, the premier reference book for practitioners at the beginner and intermediate level. * Covers new key developments in the field of PBPK modelling and simulations that have emerged in the past few years * Improves readability with completely overhauled chapters, additional figures and tables, and with more emphasis on application case studies and examples